Diabetes Insipidus Lithium
Lithium, a drug most commonly taken for bipolar disorder; up to 20% of people taking lithium will develop nephrogenic diabetes insipidus. other medicines, including demeclocycline (declomycin),. Nephrogenic diabetes insipidus (ndi) is a form of diabetes insipidus primarily due to pathology of the kidney. this is in contrast to central or neurogenic diabetes insipidus, which is caused by insufficient levels of antidiuretic hormone (adh, also called vasopressin). nephrogenic diabetes insipidus is caused by an improper response of the kidney to adh, leading to a decrease in the ability of. H is diagnosed with lithium-induced diabetes insipidus. although lithium’s exact mechanism of action is unknown, it is known that lithium can negatively affect the kidneys. 1,2 typically, antidiuretic hormone (adh) regulates water permeability in the collecting duct of the nephron, allowing water to be reabsorbed through simple diffusion in the kidney’s collecting duct (figure). 3 chronic lithium use r...